Mechano Growth Factor (MGF)
Mechano Growth Factor (MGF) is a splice variant of the insulin-like growth factor 1 (IGF-1) gene. It plays a crucial role in muscle growth and repair. MGF is produced in response to muscle damage and is involved in the process of muscle hypertrophy, which is the increase in muscle size. This peptide is released as a result of mechanical stress or muscle damage, such as that which occurs during resistance training or other forms of physical activity.
Function of MGF
MGF acts as a potent stimulator of muscle cell proliferation and differentiation. It plays a significant role in the repair and adaptation of skeletal muscle. When muscles are subjected to mechanical stress or injury, MGF is released, leading to the activation of satellite cells. Satellite cells are essential for muscle repair and growth as they can fuse with existing muscle fibers to facilitate repair and contribute to hypertrophy.
Role in Muscle Hypertrophy
The primary function of MGF is to promote muscle growth and repair. It stimulates the proliferation and differentiation of satellite cells, leading to an increase in the number of myonuclei within muscle fibers. This process contributes to muscle hypertrophy by enhancing protein synthesis and increasing the capacity for muscle growth.