Primobolan (Methenolone acetate) is a synthetic, orally active anabolic-androgenic steroid and dihydrotestosterone (DHT) derivative. It can be used for the treatment of bone marrow disease and anemia. Methenolone acetate is known for its higher therapeutic efficiency and lower hepatic toxicity compared with its 17 alpha- alkylated analogs. Methenolone cannot aromatize to estrogen, reducing estrogenic side effects, and has a favorable safety profile among anabolic agents.
Methenolone acts upon the androgen receptor stimulating anabolism through increased nitrogen retention and protein synthesis in muscle tissue. Methenolone acetate in a single dose pharmacokinetic study has demon strated a mean elimination half-life of 6 days.
As an alternate or adjunctive therapy in patients for the promotion of weight gain following weight loss and/or muscular atrophy associated with extensive surgery, chronic infections, long term hospitalization, or severe trauma. To compensate for protein catabolism consequent to corticosteroid therapy.
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