Provibolic (Mesterolone) is an oral anabolic steroid derived from dihydrotestosterone.
Provibolic (Mesterolone) is highly favored by athletes for its ability to increase androgen levels when dieting or preparing for a contest, and as an anti-estrogen due to its intrinsic ability to antagonize the aromatase enzyme.
Estrogenic Side Effects
Provibolic (Mesterolone) is not aromatized by the body, and is not measurably estrogenic. An anti-estrogen is not necessary when using this steroid, as the drug is unlikely to induce gynecomastia, water retention, or other estrogen-related side effects.
Androgenic Side Effects
Provibolic (Mesterolone) is classified as an androgenic steroid. Androgenic side effects are common with this substance, especially with higher doses. This may include bouts of oily skin, acne, and body/facial hair growth.
Anabolic/androgenic steroids may also aggravate male pattern hair loss.
Women are also warned of the potential virilizing effects of anabolic/androgenic steroids. These may include a deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement.
Hepatotoxicity Side Effects
Provibolic (Mesterolone) is not c17-alpha alkylated, and not known to produce hepatotoxic effects; liver toxicity is unlikely.
Cardiovascular Side Effects
Anabolic/androgenic steroids can have deleterious effects on serum cholesterol. This includes a tendency to reduce HDL (good) cholesterol values and increase LDL (bad) cholesterol values, which may shift the HDL to LDL balance in a direction that favors greater risk of arteriosclerosis.
The relative impact of an anabolic/androgenic steroid on serum lipids is dependant on the dose, route of administration (oral vs. injectable), type of steroid (aromatizable or non-aromatizable), and level of resistance to hepatic metabolism.
Anabolic/androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, all potentially increasing the risk of cardiovascular disease and myocardial infarction.
Provibolic (Mesterolone) should not be used when cardiovascular risk factors preclude the use of other oral steroids.
To help reduce cardiovascular strain, it is advised to maintain an active cardiovascular exercise program and minimize the intake of saturated fats, cholesterol, and simple carbohydrates at all times during active steroid administration. Supplementing with fish oils and a natural cholesterol/antioxidant formula is also recommended.
All anabolic/androgenic steroids are expected to suppress endogenous testosterone production. Testosterone is the primary male androgen, and offers strong negative feedback on endogenous testosterone production.
Provibolic (Mesterolone) has a very weak suppressive effect on gonadotropins and serum testosterone. Studies show that when given in moderate doses (150 mg per day or less), significant suppression of testosterone levels does not occur. In studies with higher doses (300 mg per day and above), the agent strongly suppressed serum testosterone.
Testosterone-based drugs will, likewise, have a strong effect on the hypothalamic regulation of natural steroid hormones. Without the intervention of testosterone-stimulating substances, testosterone levels should return to normal within 1-4 months of drug secession.
Note that prolonged hypogonadotrophic hypogonadism can develop secondary to steroid abuse, necessitating medical intervention.
Administration for Men
It is most commonly used at a dosage of 50-150mg per day.
The positive effects of this drug become most apparent when it is used for longer cycles, usually lasting 6-12 weeks.
Provibolic (Mesterolone) is a very versatile drug, and can be combined with a number of other agents depending on the desired result.
Administration for Women
Provibolic (Mesterolone) is rarely used with women in clinical medicine.
Provibolic (Mesterolone) is not recommended for women for performance enhancing purposes due to its strong androgenic nature and tendency to produce virilizing side effects.
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