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Hilmabiocare Letrozole 2.5mg/30tabs (EXP. 03/2024)

£15.00

Letrozole is a nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase

inhibitor, Letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells.

Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.

Estrogens are produced by the conversion of androgens through the activity of the aromatase enzyme. Letrozole blocks production of estrogens in this way by competitive, reversible binding to the heme of its cytochrome P450 unit. The action is specific, and letrozole does not reduce production of mineralo- or corticosteroids. In contrast, the antiestrogenic action of tamoxifen, the major medical therapy prior to the arrival of aromatase inhibitors, is due to its interfering with the estrogen receptor, rather than inhibiting estrogen production.

Letrozole is approved by the United States Food and Drug Administration (FDA) for the treatment of local or metastatic breast cancer that is hormone receptor positive or has an unknown receptor status in postmenopausal women. Side effects include signs and symptoms of hypoestrogenism. There is concern that long term use may lead to osteoporosis, which is why prescriptions of Letrozole are often accompanied by prescriptions of osteoporosis-fighting medication such as Fosamax.

Letrozole has shown to reduce estrogen levels by 98 percent while raising testosterone levels.

The anti-estrogen action of letrozole is preferred by athletes and bodybuilders for use during a steroid cycle to reduce bloating due to excess water retention and prevent the formation of gynecomastia related breast tissue that is a side effect of some anabolic steroids. Usage above 2.5 mg/day is known to potentially temporarily kill sex drive. Above 5mg/day for extended periods may cause kidney problems.

Letrozole has also been shown to delay the fusing of the growth plates in adolescents. This may boost the effectiveness of growth hormone, and thus Letrozole is used to treat adolescents and children with short stature.

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SKU: hilmabiocare-letrozole-25 Categories: , , ,

Description

 

Specifications:

Company: Hilma Biocare
Active Half-life (Days):  2-3 days
Group: Aromatase inhibitor
Subgroup: Oral/tablets
Dosage: 2.5 mg/tab
Application (Men): 0.5 to 1 mg throughout 1 to 3 days
Product pack: 30 tab.
Content (active): Letrozole
Retains water: No
Aromatization: No

Product Description

Letrozole is an antitumor agent, a non-steroidal selective inhibitor of the aromatase enzyme. Widely used in medicine as a part of post-menopausal therapy in women and breast cancer treatment. Among athletes gained recognition for strong anti-estrogenic properties and raised muscle definition. Like Anastroloze(Arimidex), its effect is up to 5 times stronger, eliminating adverse reactions from anabolic steroid use. Letrozole can suppress estrogen levels in the body, almost wholly shielding from raised estradiol levels.

Effects:

By using Letrozole athletes can almost wholly suppress estrogen level in the body and protects themselves against aromatization.

Side-Effects:

The most common side effects attributed to Letrozole are skin rash, nausea, abdominal pain, fatigue, dizziness, headache, raised Low-density cholesterol levels and liver enzymes.

Protection:

Preliminary blood test should be conducted before using Letrozole. Results in colossal estradiol reduction and increasing the effectiveness of your cycle. Letrozole served as an anti-estrogenic drug and was used as a part of PCT.

Stacking:

Letrozole is most effective during PCT but can be stacked with clomiphene or other steroids as a part of the cycle.

 

Protection code:

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Hilma Biocare™ takes care of consumers and regularly develops various means of protecting its products, which ensures patient safety and trust to verify our products

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Additional information

Brand

Hilma Biocare

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